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Bibliographie

176 Maladie de Waldenström ou macroglobulinémie
Leblond V, Tournilhac O, Morel P.
EMC in press 2006

175 High Mda-7 expression promotes malignant cell survival and p38 MAP kinase activation in chronic lymphocytic leukemia.
Sainz-Perez A, Gary-Gouy H, Portier A, Davi F, Merle-Beral H, Galanaud P, Dalloul A.
Leukemia. 2006 Mar; 20(3):498-504

174 Abnormal levels of the alpha chain of the CD22 adhesion molecule may account for low CD22 surface expression in chronic lymphocytic leukaemia
Payelle-Brogard B, Dumas G, Magnac C, Lalanne AI, Dighiero G, Vuillier F
Leukemia. Feb 23 (2006)

173 Update on treatment recommendations from the Third International Workshop on Waldenstrom's Macroglobulinemia
Treon SP, Gertz MA, Dimopoulos M, Anagnostopoulos A, Blade J, Branagan AR, Garcia-Sanz R, Johnson S, Kimby E, Leblond V et al
Blood. Jan 12 (2006) (Epub eahead of print)

172 Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia
Binet JL, Caligaris-Cappio F, Catovsky D, Cheson B, Davis T, Dighiero G, et al
Blood. Feb 1;107(3):859-61 (2006)

171 La maladie de Waldenström ou Macroglobulinémie.
Leblond V, Tournilhac O.
Hématologie, 2005; 11: 408-416

170 CLL biology and prognosis
Dighiero G
Hematology (Am Soc Hematol Educ Program). 278-84 (2005)

169 What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis ?
Opezzo P, Dighiero G
Curr Top Microbiol Immunol. 294:71-89 (2005)

168 Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains
Vuillier F, Dumas G, Magnac C, Prevost MC, Lalanne AI, Oppezzo P, et al
Blood. Apr 1;105(7):2933-40 (2005)

167 Gene expression profiling of chronic lymphocytic leukemia can discriminate cases with stable disease and mutated Ig genes from those with progressive disease and unmutated Ig genes
Vasconcelos Y, De Vos J, Vallat L, Reme T, Lalanne AI, Wanherdrick K, et al
Leukemia. Nov;19(11):2002-5 (2005)

166 Report of the Third International Workshop on Waldenstrom's macroglobulinemia
Treon SP, Morel P, Leblond V, Fermand JP
Clin Lymphoma. Mar;5(4):215-6 (2005)

165 Fludarabine plus cyclophosphamide in Waldenstrom's macroglobulinemia: results in 49 patients
Tamburini J, Levy V, Chaleteix C, Fermand JP, Delmer A, Stalniewicz L, et al
Leukemia. Oct;19(10):1831-4 (2005)

164 The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia
Oppezzo P, Vasconcelos Y, Settegrana C, Jeannel D, Vuillier F, Legarff-Tavernier M, et al
Blood. Jul 15;106(2):650-7 (2005)

163 Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells
Oppezzo P, Dumas G, Lalanne AI, Payelle-Brogard B, Magnac C, Pritsch O, et al
Blood. Mar 15;105(6):2495-503 (2005)

162 What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis?
Oppezzo P, Dighiero G
Curr Top Microbiol Immunol.;294:71-89 (2005)

161 Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations
Mackey JR, Galmarini CM, Graham KA, Joy AA, Delmer A, Dabbagh L, et al
Blood. Jan 15;105(2):767-74 (2005)

160 Advanced Waldenstrom's macroglobulinemia: usefulness of Morel's scoring system in establishing prognosis
Levy V, Morel P, Porcher R, Chevret S, Wattel E, Leblond V
Haematologica. Feb;90(2):279-81 (2005)

159 Waldenstrom's macroglobulinemia and bortezomib
Leblond V
Haematologica. Dec;90(12):1589A (2005)

158 Phase III study of chlorambucil versus fludarabine as initial therapy for Waldenstrom's macroglobulinemia and related disorders
Johnson SA, Owen RG, Oscier DG, Leblond V, Levy V, Jaeger U, et al
Clin Lymphoma. Mar;5(4):294-7 (2005)

157 Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene
Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stella S, Guida G, et al
Blood. Feb 15;105(4):1678-85 (2005)

156 How we treat Waldenstrom's macroglobulinemia
Dimopoulos MA, Merlini G, Leblond V, Anagnostopoulos A, Alexanian R
Haematologica. Jan;90(1):117-25 (2005)

155 Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathways
Deriano L, Guipaud O, Merle-Béral H, Binet JL, Ricoul M, Potocki-Veronese G, Favaudon V, Maciorowski Z, Muller C, Salles B, Sabatier L, Delic J
Blood. Jun 15;105(12):4776-83 (2005)

154 CLL Biology and Prognosis
Dighiero G
Hematology (Am Soc Hematol Educ Program).:278-84 (2005)

153 Leucémie Lymphoïde Chronique.
 Merle-Beral H
Hématologie Clinique et Biologique (2ème édition). Editions Arnette: 2005, 285-292.

152 Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway
Deriano L, Guipaud O, Merle-Beral H, Binet JL, Ricoul M, Potocki-Veronese G, et al
Blood. Jun 15;105(12):4776-83 (2005)

151 Burkitt-type acute leukemia in a patient with B-prolymphocytic leukemia: evidence for a common origin.
Nguyen-Khac F, Davi F, Receveur A, Maloum K, Morel V, Le Garff –Tavernier M, Ong J, Berger R, V Leblond, Merle-Béral H.
Cancer Genetics and Cytogenetics. 2005, (159) : 74-78.

150 Immunophenotypic approach to the identification and charaterization of clonal plasma cells from patients with monoclonal gammopathies.
Pérez-Andrés M, Santiago M, Almeida J, Mateo G, Porwit-MacDonald A, Bjorklund E, Valet G, Kraan J, Gratama JW, D’Hautcourt JL, Merle-Béral H, Lima M, Montalban MA, San Miguel JF, Orfao A; for the European Working Group on Clinical Cell Analysis (EWGCCA) and the Spanish Network on Multiple Myeloma.
J Biol Regul and Homeost Agents 2004; 18:392-398.

149 Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia
Tournilhac O, Cazin B, Lepretre S, Divine M, Maloum K, Delmer A, et al
Blood. Jan 1;103(1):363-5 (2004)

148 hTERT expression and prognosis in B-chronic lymphocytic leukemia
Tchirkov A, Chaleteix C, Magnac C, Vasconcelos Y, Davi F, Michel A, et al
Ann Oncol. Oct;15(10):1476-80 (2004)

147 Role of fludarabine as monotherapy in the treatment of chronic lymphocytic
Leporrier M
leukemia Hematol J.;5 Suppl 1:S10-9 (2004)

146 Chronic lymphocytic leukemia
Leporrier M
Rev Prat. Feb 29;54(4):359-67 (2004)

145 Waldenstrom's macroglobulinemia: prognostic factors and recent therapeutic advances
Leblond V, Tournilhac O, Morel P
Clin Exp Med. Apr;3(4):187-98 (2004)

144 Perspectives in chronic lymphocytic leukemia biology and management
Dighiero G
Hematol Oncol Clin North Am. Aug;18(4):927-43, x (2004)

143 Patient management decisions in chronic lymphocytic leukemia: an introduction and an editorial
Binet JL
Semin Hematol. Jul;41(3):191 (2004)

142 Fludarabine in chronic lymphocytic leukemia and other hematological malignancies: progress in treatment. Fludarabine supplement
Binet JL
Hematol J.;5 Suppl 1:S1 (2004)

141 B-cell chronic lymphocytic leukaemia : a polymorphic family unified by genomic features.
Guipaud O, Deriano L, Salin H, Vallat L, Sabatier L, Merle-Béral H, Delic J.
Lancet Oncology. 2003;4 :505-514.

140 Idiotype-pulsed dendritic cells are able to induce antitumoral cytotoxic CD8 cells in chronic lymphocytic leukaemia
Vuillier F, Maloum K, Thomas EK, Magnac C, Dumas G, Payelle-Brogard B, et al
Br J Haematol. Jan;120(2):243-50 (2003)

139 Monocyte-derived dendritic cells in chronic lymphocytic leukemia
Vuillier F, Dighiero G
Leuk Lymphoma. Aug;44(8):1267-73 (2003)

138 Cell therapy by dendritic cells in chronic lymphoid leukemia: state of the art
Vuillier F, Dighiero G
Bull Cancer. Aug-Sep;90(8-9):744-50 (2003)

137 Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia
Vasconcelos Y, Davi F, Levy V, Oppezzo P, Magnac C, Michel A, et al
J Clin Oncol. Nov 1;21(21):3928-32 (2003)

136 Transplantation in Waldenstrom's macroglobulinemia--the French experience
Tournilhac O, Leblond V, Tabrizi R, Gressin R, Senecal D, Milpied N, et al
Semin Oncol. Apr;30(2):291-6 (2003)

135 Prognostic factors in Waldenstrom's macroglobulinemia: description of the complications during the evolution-preliminary results on 101 patients
Stalnikiewicz L, Carrotte-Lefebvre I, Detourmignies L, Rose C, Cazin B, Leblond V, et al
Semin Oncol. Apr;30(2):216-9 (2003)

134 Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells
Sarfati M, Mateo V, Baudet S, Rubio M, Fernandez C, Davi F, et al
Blood. Jan 1;101(1):265-9 (2003)

133 Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases
Sanhes L, Tang R, Delmer A, DeCaprio JA, Ajchenbaum-Cymbalista F
Leukemia. Jun;17(6):1104-11 (2003)

132 Dysfunction of the Fas apoptotic signaling pathway in persistent polyclonal B-cell lymphocytosis
Roussel M, Roue G, Sola B, Mossafa H, Troussard X
Haematologica. Feb;88(2):239-40 (2003)

131 Expression of the two alternative [a] and [b] transcripts of CCND1 gene in cyclin D1-expressing B-malignancies: relevance for the pathogenesis
Roue G, Krieger S, Florent M, Roussel M, Duquesne F, Troussard X, et al
Leukemia. Mar;17(3):652-5 (2003)

130 Retention and defective assembly of the B-cell receptor in the endoplasmic reticulum of chronic lymphocytic leukaemia B cells cannot be reverted upon CD40 ligand stimulation
Payelle-Brogard B, Magnac C, Oppezzo P, Dumas G, Dighiero G, Vuillier F
Leukemia. Jun;17(6):1196-9 (2003)

129 Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation
Oppezzo P, Vuillier F, Vasconcelos Y, Dumas G, Magnac C, Payelle-Brogard B, et al
Blood. May 15;101(10):4029-32 (2003)

128 Predictive value of serum thymidine kinase level for Ig-V mutational status in B-CLL
Magnac C, Porcher R, Davi F, Nataf J, Payelle-Brogard B, Tang RP, et al
Leukemia. Jan;17(1):133-7 (2003)

127 Fludarabine in Waldenstrom's macroglobulinemia
Leblond V, Choquet S
Semin Oncol. Apr;30(2):239-42 (2003)

126 Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia
Kyle RA, Treon SP, Alexanian R, Barlogie B, Bjorkholm M, Dhodapkar M, et al
Semin Oncol. Apr;30(2):116-20 (2003)

125 Unsolved issues in CLL biology and management
Dighiero G
Leukemia. Dec;17(12):2385-91 (2003)

124 High levels of chromosome aberrations correlate with impaired in vitro radiation-induced apoptosis and DNA repair in human B-chronic lymphocytic leukaemia cells.
Blaise R, Alapetite C, Masdehors P, Merle-Beral H, Roulin C, Delic J, Sabatier L.
Int J Radiat Biol. 2002 Aug;78(8):671-9.

123 High occurence of DRB1 11 in chronic lymphocytic leukaemia families
Theodorou I, Abel L, Mauro F, Duprey B, Magnac C, Payelle-Brogard B, et al
Br J Haematol. Dec;119(3):713-5 (2002)

122 Dicentric chromosome 3 associated with binucleated lymphocytes in atypical B-cell chronic lymphoproliferative disorder
Samson T, Mossafa H, Lusina D, Fagot T, Souleau B, de Revel T, et al
Leuk Lymphoma. Sep;43(9):1749-54 (2002)

121 Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia
Payelle-Brogard B, Magnac C, Alcover A, Roux P, Dighiero G
Br J Haematol. Sep;118(4):976-85 (2002)

120 Do CLL B cells correspond to naive or memory B-lymphocytes? Evidence for an active Ig switch unrelated to phenotype expression and Ig mutational pattern in B-CLL cells
Oppezzo P, Magnac C, Bianchi S, Vuillier F, Tiscornia A, Dumas G, et al
Leukemia. Dec;16(12):2438-46 (2002)

119 Novel flow-cytometric analysis based on BCD5+ subpopulations for the evaluation of minimal residual disease in chronic lymphocytic leukaemia
Maloum K, Sutton L, Baudet S, Laurent C, Bonnemye P, Magnac C, et al
Br J Haematol. Dec;119(4):970-5 (2002)

118 Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study
Keating MJ, Flinn I, Jain V, Binet JL, Hillmen P, Byrd J, et al
Blood. May 15;99(10):3554-61 (2002)

117 Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed
Keating MJ, Cazin B, Coutre S, Birhiray R, Kovacsovics T, Langer W, et al
J Clin Oncol. Jan 1;20(1):205-13 (2002)

116 Waldenstrom's macroglobulinaemia
Johnson SA, Oscier DG, Leblond V
Blood Rev. Sep;16(3):175-84 (2002)

115 Cleaved lymphocytes in chronic lymphocytic leukemia: a detailed retrospective analysis of diagnostic features
Gonzalez H, Maloum K, Remy F, Merle-Beral H, Lesty C
Leuk Lymphoma. Mar;43(3):555-64 (2002)

114 Is chronic lymphocytic leukemia one disease?
Dighiero G
Haematologica. Dec;87(12):1233-5 (2002)

113 Chronic lymphoid leukemia: a single disease or 2 distinct diseases?
Dighiero G
Bull Acad Natl Med. 186(7):1251-66; discussion 66-8 (2002)

112 Functional monocyte-derived dendritic cells can be generated in chronic lymphocytic leukaemia
Vuillier F, Maloum K, Thomas EK, Jouanne C, Dighiero G, Scott-Algara D
Br J Haematol. Dec;115(4):831-44 (2001)

111 Upstream mediators of the Fas apoptotic transduction pathway are defective in B-chronic lymphocytic leukemia
Roue G, Lancry L, Duquesne F, Salaun V, Troussard X, Sola B
Leuk Res. Nov;25(11):967-80 (2001)

110 Evaluating treatment strategies in advanced Waldenstrom macroglobulinemia: use of quality-adjusted survival analysis
Levy V, Porcher R, Leblond V, Fermand JP, Cazin B, Maloisel F, et al
Leukemia. Sep;15(9):1466-70 (2001)

109 Evaluating treatment strategies in chronic lymphocytic leukemia: use of quality-adjusted survival analysis
Levy V, Porcher R, Delabarre F, Leporrier M, Cazin B, Chevret S
J Clin Epidemiol. Jul;54(7):747-54 (2001)

108 Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
Leporrier M, Chevret S, Cazin B, Boudjerra N, Feugier P, Desablens B, et al
Blood. Oct 15;98(8):2319-25 (2001)

107 Multicenter, randomized comparative trial of fludarabine and the combination of cyclophosphamide-doxorubicin-prednisone in 92 patients with Waldenstrom macroglobulinemia in first relapse or with primary refractory disease
Leblond V, Levy V, Maloisel F, Cazin B, Fermand JP, Harousseau JL, et al
Blood. Nov 1;98(9):2640-4 (2001)

106 Activity of oral fludarabine phosphate in previously treated chronic lymphocytic leukemia
Boogaerts MA, Van Hoof A, Catovsky D, Kovacs M, Montillo M, Zinzani PL, et al
J Clin Oncol. Nov 15;19(22):4252-8 (2001)

105 Chromosomal DNA and p53 stability, ubiquitin system and apoptosis in B-CLL lymphocytes
Blaise R, Masdehors P, Lauge A, Stoppa-Lyonnet D, Alapetite C, Merle-Beral H, et al
Leuk Lymphoma. Nov-Dec;42(6):1173-80 (2001)

104 Ubiquitin-proteasome system and increased sensitivity of B-CLL lymphocytic apoptotic death activation.
Masdehors P, Merle-Béral H, Magdelenat H, Delic J.
Leukemia and Lymphoma, 2000, 38: 499-504.

103 Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia
Maloum K, Davi F, Merle-Beral H, Pritsch O, Magnac C, Vuillier F, et al
Blood. Jul 1;96(1):377-9 (2000)

102 Prognostic relevance of a scoring system based on clinical and biological parameters in early chronic lymphocytic leukemia
Leotard S, Chastang C, Travade P, Jaudon MC, Tournilhac O, Baudet S, et al
Hematol J.;1(5):301-6 (2000)

101 When and how to treat chronic lymphocytic leukemia
Dighiero G, Binet JL
N Engl J Med. Dec 14;343(24):1799-801 (2000)

100 Emerging therapies and future directions in CLL--monoclonal antibodies, vaccines and gene therapy
Binet JL
Hematol Cell Ther. Jun;42(1):49-51 (2000)

99 Theophylline-induced B-CLL apoptosis is partly dependant on cyclic AMP production but independent of CD38 expression and endogenous IL-10 production.
Mentz F, Merle-Beral H, Dalloul Ali. H.
Leukemia. 1999, 13, N°1, 78-84

98 Transcriptional and post-transcriptional mechanisms induce cyclin-D1 over-expression in B-chronic lymphoproliferative disorders
Sola B, Salaun V, Ballet JJ, Troussard X
Int J Cancer. Oct 8;83(2):230-4 (1999)

97 VH gene usage by family members affected with chronic lymphocytic leukaemia
Pritsch O, Troussard X, Magnac C, Mauro FR, Davi F, Payelle-Brogard B, et al
Br J Haematol. Dec;107(3):616-24 (1999)

96 Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic
Payelle-Brogard B, Magnac C, Mauro FR, Mandelli F, Dighiero G
leukemia Blood. Nov 15;94(10):3516-22 (1999)

95 Heterogeneity of serum IgG subclass deficiencies in B chronic lymphocytic leukemia.
Lacombe C, Gombert J, Dreyfus B, Brizard A, Preud'homme JL.
Clin Immunol. 1999 Jan;90(1):128-32

94 Detection of minimal residual disease in B chronic lymphocytic leukemia (CLL)
Magnac C, Sutton L, Cazin B, Laurent C, Binet JL, Merle-Beral H, et al
Hematol Cell Ther. Feb;41(1):13-8 (1999)

93 Chronic lymphoid leukemia. Diagnosis, course, prognosis, principles of treatment
Cheze S, Leporrier M
Rev Prat. Mar 1;49(5):539-46 (1999)

92 Prognostic factors in chronic lymphocytic leukaemia
Binet JL
Haematologica. Jun;84 Suppl EHA-4:96-7 (1999)

91 B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity
Zhao H, Dugas N, Mathiot C, Delmer A, Dugas B, Sigaux F, et al
Blood. Aug 1;92(3):1031-43 (1998)

90 Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic B-cell lymphocytic leukemia
Vrhovac R, Delmer A, Tang R, Marie JP, Zittoun R, Ajchenbaum-Cymbalista F
Blood. Jun 15;91(12):4694-700 (1998)

89 Autologous hematopoietic stem cell transplantation as salvage treatment for advanced B cell chronic lymphocytic leukemia
Sutton L, Maloum K, Gonzalez H, Zouabi H, Azar N, Boccaccio C, et al
Leukemia. Nov;12(11):1699-707 (1998)

88 Basic biology of autoimmune phenomena in chronic lymphocytic leukemia
Pritsch O, Maloum K, Dighiero G
Semin Oncol. Feb;25(1):34-41 (1998)

87 Simple, fast method of detection apoptosis in lymphoid cells
Mentz F, Baudet S, Blanc C, Issaly F, Binet JL, Merle-Beral H
Cytometry. Jun 1;32(2):95-101 (1998)

86 VH gene expression in hairy cell leukaemia
Maloum K, Magnac C, Azgui Z, Cau C, Charlotte F, Binet JL, et al
Br J Haematol. Apr;101(1):171-8 (1998)

85 Activity of fludarabine in previously treated Waldenstrom's macroglobulinemia: a report of 71 cases.
Leblond V, Ben-Othman T, Deconinck E, Taksin AL, Harousseau JL, Delgado MA, et al. Groupe Cooperatif Macroglobulinemie
J Clin Oncol. Jun;16(6):2060-4 (1998)

84 Chlorambucil in indolent chronic lymphocytic leukemia
Dighiero G, Maloum K, Desablens B, Cazin B, Navarro M, Leblay R, et al. French Cooperative Group on Chronic Lymphocytic Leukemia
N Engl J Med. May 21;338(21):1506-14 (1998)

83 Autoimmunity and B-cell malignancies
Dighiero G
Hematol Cell Ther. Feb;40(1):1-9 (1998)

82 Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells.
Semichon M, Merle-Beral H, Lang V and Bismuth G.
Leukemia: 1997, 11, 1921-1928.

81 Soluble Fcg Receptor, Fcg RIIa2, exists under two forms in human serum and is increased in patients with stage C of B Chronic Lymphocytic Leukemia.
Astier A, Merle-Beral H, De La Salle H, Moncuit J, Cazenave J.P, Herman Fridman W, Hanau D, Teillaud J.L.
Leukemia and Lymphoma: 1997, 26, 317-326.

80 What do chronic B cell malignancies teach us about B cell subsets?
Pritsch O, Maloum K, Magnac C, Davi F, Binet JL, Merle-Beral H, et al
Chem Immunol.;67:85-101 (1997)

79 VH gene expression in CD5 positive and CD5 negative B cell chronic lymphoid malignancies
Maloum K, Pritsch O, Magnac C, Davi F, Binet JL, Merle-Beral H, et al
Leuk Lymphoma. Feb;24(5-6):437-48 (1997)

78 Minimal residual disease detection in B-cell malignancies by assessing IgH rearrangement
Maloum K, Pritsch O, Dighiero G
Hematol Cell Ther. Jun;39(3):119-24 (1997)

77 Chronic lymphocytic leukemia treatment
Dighiero G
Hematol Cell Ther. Nov;39 Suppl 1:S31-40 (1997)

76 11q13 rearrangement in B cell chronic lymphocytic leukemia.
Brizard F, Dreyfus B, Guilhot F, Tanzer J, Brizard A.
Leuk Lymphoma.1997 May;25(5-6):539-43

75 High incidence of serum monoclonal IgS detected by a sensitive immunoblotting technique in B-cell chronic lymphocytic leukemia.
Beaume A, Brizard A, Dreyfus B, Preud'homme JL.
Blood.1994 Aug 15;84(4):1216-9

74 Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia
Sarfati M, Chevret S, Chastang C, Biron G, Stryckmans P, Delespesse G, et al
Blood. Dec 1;88(11):4259-64 (1996)

73 Theophylline synergizes with chlorambucil in inducing apoptosis of B-chronic lymphocytic leukemia cells
Mentz F, Mossalayi MD, Ouaaz F, Baudet S, Issaly F, Ktorza S, et al
Blood. Sep 15;88(6):2172-82 (1996)

72 What is the CLL B-lymphocyte?
Dighiero G, Kipps T, Schroeder HW, Chiorazzi N, Stevenson F, Silberstein LE, et al
Leuk Lymphoma. Oct;22 Suppl 2:13-39 (1996)

71 Chronic lymphocytic leukemia
Dighiero G, Binet JL
Hematol Cell Ther. Dec;38 Suppl 2:S41-61 (1996)

70 Adverse and beneficial immunological effects of purine nucleoside analogues
Dighiero G
Hematol Cell Ther. Dec;38 Suppl 2:S75-81 (1996)

69 What does apoptosis mean in CLL?
Binet JL, Plunkett W, Robertson B, Merle-Beral H, Mentz F, Hoffbrand AV, et al
Leuk Lymphoma. Oct;22 Suppl 2:47-52 (1996)

68 Theophylline, a new inducer of apoptosis in B-CLL. Role of cyclic nucleotides.
Mentz F, Merle-Beral H, Ouaaz F, Dmossalyi M, Binet J.L.
British J of Haematol.: 1995, 90, 957-959.

67 A scoring system for the classification of CD5-B CLL versus CD5+B CLL and B PLL.
Salomon-Nguyen F, Valensi F, Merle-Beral H, Flandrin G.
Leukemia and Lymphoma: 1995, 16, 445-450.

66 Theophylline, a new inducer of apoptosis in B-CLL: role of cyclic nucleotides
Mentz F, Merle-Beral H, Ouaaz F, Binet J
Br J Haematol. Aug;90(4):957-9 (1995)

65 Analysis of VH gene expression in CD5+ and CD5- B-cell chronic lymphocytic leukemia
Maloum K, Davi F, Magnac C, Pritsch O, McIntyre E, Valensi F, et al
Blood. Nov 15;86(10):3883-90 (1995)

64 Synergistic action of alkylating agents and methylxanthine derivatives in the treatment of chronic lymphocytic leukemia
Binet JL, Mentz F, Leblond V, Merle-Beral H
Leukemia. Dec;9(12):2159-61 (1995)

63 In vitro induction of apoptosis in chronic lymphoid leukemia B lymphocytes by theophylline: therapeutic applications
Binet JL, Mentz F, Baudet S, Ouaaz F, Merle-Beral H
Bull Acad Natl Med. Oct;179(7):1379-91; discussion 91-2 (1995)

62 Proliferative response of B chronic lymphocytic leukemia lymphocytes stimulated with IL2 and soluble CD23.
Brizard A, Morel F, Lecron JC, Dreyfus B, Brizard F, Barra A, Preud'homme JL.
Leuk Lymphoma. 1994 Jul;14(3-4):311-8

61 The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire
Schroeder HW, Jr., Dighiero G
Immunol Today. Jun;15(6):288-94 (1994)

60 Chronic lymphoproliferative disorders
Montserrat E, Binet JL, Dighiero G, Gale RP, Juliusson G, Keating M, et al
Rev Invest Clin. Apr;Suppl:52-8 (1994)

59 Recent progress in chronic lymphocytic leukemia
Gale RP, Caligaris-Cappio F, Dighiero G, Keating M, Montserrat E, Rai K. International Workshop on chronic Lymphocytic Leukemia
Leukemia. Sep;8(9):1610-4 (1994)

58 Autoantibody activity and V gene usage by B-cell malignancies
Dighiero G
Adv Exp Med Biol. 347:125-33 (1994)

57 Chromosomal analysis of purified B-chronic lymphocytic leukemia lymphocyte cultures: comparison with whole blood cultures and in situ hybridization
Brizard A, Brizard F, Dreyfus B, Morel F, Lecron JC, Tanzer J, Preud'homme JL.
Leuk Lymphoma.1993 Nov;11(5-6):379-85

56 Potential immunological action of purine nucleoside analogues
Dighiero G
Drugs. 47 Suppl 6:57-62 (1994)

55 Defective calcium response in B-chronic lymphocytic leukemia cells : alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx.
Michel F, Merle-Beral H, Legac E, Michel A, Debre P, Bismuth G.
J. Immunol.: 1993, 150, 3624-3633.

54 Improvement of cytogenetic results in B-cell chronic lymphocytic leukemia using immuno-purified leukemic cells.
Brizard A, Brizard F, Lessard M, Dreyfus B, Guilhot F, Tanzer J.
Nouv Rev Fr Hematol. 1993 Feb;35(1):103-5

53 Biology of the neoplastic lymphocyte in B-CLL
Dighiero G
Baillieres Clin Haematol. Dec;6(4):807-20 (1993)

52 Treatment of chronic lymphocytic leukaemia
Binet JL. French Co-operative Group on CLL
Baillieres Clin Haematol. Dec;6(4):867-78 (1993)

51 Fludarabine phosphate in chronic lymphoproliferative diseases
Binet JL. The French Group on CLL
Nouv Rev Fr Hematol. Feb;35(1):5-7 (1993)

50 When and how to treat elderly patients with chronic lymphocytic leukemia (C.L.L.)?
Binet JL. The French Cooperative Group on C.L.L
Hematol Oncol. 11 Suppl 1:38 (1993)

49 Evaluation of residual disease in B-cell chronic lymphocytic leukemia patients in clinical and bone-marrow remission using CD5-CD19 markers and PCR study of gene rearrangement
Vuillier F, Claisse JF, Vandenvelde C, Travade P, Magnac C, Chevret S, et al
Leuk Lymphoma. Jun;7(3):195-204 (1992)

48 5th International Workshop on Chronic Lymphocytic Leukemia
Montserrat E, Binet JL, Catovsky D, Dighiero G, Gale RP, Rai KR, et al
Leuk Res. Jun-Jul;16(6-7):717-20 (1992)

47 CD1c is not a feature of mixed-cell type but of a typical form of chronic lymphocytic leukaemia
Merle-Beral H, Legac E, Chastang C, Michel A, Debre P, Binet JL
Eur J Haematol. Feb;48(2):120 (1992)

46 B-cell chronic lymphocytic leukemia: present status and future directions
Dighiero G, Travade P, Chevret S, Fenaux P, Chastang C, Binet JL. French Cooperative Group on CLL.
 Blood. Oct 15;78(8):1901-14 (1991)

45 Homozygote breakpoint in 13q14 in a case of chronic lymphocytic leukemia.
Huret JL, Brizard A, Dreyfus B, Tanzer J.
Cancer Genet Cytogenet. 1991 Dec;57(2):231-2 

44 A further characterization of B-CLL lymphocytes : phenotypic and functional studies.
Merle-Beral H.
Nouv. Rev. Fr. Hématol.: 1990, 32, 319-321.

43 IL4 inhibits the expression of high affinity IL2 receptors on monoclonal human Bcells.
Karray S, Dautry-Versat A, Merle-Beral H, Debre P, Galanaud P.
J. Immunol.: 1990, 145, 1152-1158.

42 B8.7 antigen expression on B-CLL and its relationship to the LMW-BCGF reponsiveness.
Karray S, Leprince C, Merle-Beral H, Debre P, Richard Y, Galanaud P.
Leukemia Res.: 1990, 14, 809-814.

41 The experience of the French Cooperative Group in the treatment of CLL
Travade P
Nouv Rev Fr Hematol. 32(5):313-7 (1990)

40 Evidence that the B lymphocyte proliferating in B-CLL and in other B-cell malignancies is frequently committed to production of natural autoantibodies
Dighiero G, Borche L
Nouv Rev Fr Hematol. 32(5):323-6 (1990)

39 Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies
Borche L, Lim A, Binet JL, Dighiero G
Blood. Aug 1;76(3):562-9 (1990)

38 Karyotypes of 33 patients with clonal aberrations in chronic lymphocytic leukemia. Review of 216 abnormal karyotypes in chronic lymphocytic leukemia.
Huret JL, Mossafa H, Brizard A, Dreyfus B, Guilhot F, Xue XQ, Babin P, Tanzer J.
Ann Genet.1989;32(3):155-9

37 The lymphocytes of chronic lymphoid leukemia. Diagnostic, physiologic and prognostic significance
Binet JL
Bull Acad Natl Med. Jan;173(1):73-6; discussion 7 (1989)

36 CD1 expression in B-CLL cells.
H. Merle-Beral, L. Boumsell, A. Michel, C. Blanc, P. Debre.
Nouv. Rev. Fr. Hématol.: 1988, 30, 327-330.

35 Interleukin 4 counteracts the interleukin 2 induced proliferation of monoclonal Bcells.
S. Karray, T. Defrance, H. Merle-Beral, J. Banchereau, P. Debre, P. Galanaud.
J. Exp. Med.: 1988, 168, 85-89.

34 Positive effet on IFNa on B-CLL lymphocytes proliferative response.
S. Karray, J.F. Delfraissy, H. Merle-Beral, P. Debre, P. Galanaud.
J. Immunol.: 1988, 140, 774-778.

33 Induction of differentiation in human leukemic B cells by IL2 alone : differential effect on the expression of MU and J chain genes.
Emilie D., Karray S., Merle-Beral H., Debre P., Galanaud P..
Eur. J. Immuno.: 1988, 18, 1479-1483.

32 Phenotypic heterogeneity of B and T cell antigen in B-CLL
Merle-Beral H, Chastang C, Blanc C, Debré P
Eur J Haematol, 41, 197-203 ( 1988)

31 Lymph node biopsy in chronic lymphocytic leukemia: prognostic significance of histopathological, morphometry and immunohistological findings
Raphael M, Debre P, Guigui B, Binet JL
Nouv Rev Fr Hematol. 30(5-6):379-83 (1988)

30 Is bone marrow biopsy a prognostic parameter in B-CLL?
Raphael M, Chastang C, Binet JL
Nouv Rev Fr Hematol. 30(5-6):377-8 (1988)

29 Comparison of the (A, B, C) staging and the Rai’s staging from a large prospective series (935 patients)
French Cooperative Group on Chronic Lymphocytic Leukemia
Nouv. Rev. Fr. Hématol. 30, 363-367 (1988)

28  Functional heterogeneity of B-CLL lymphocytes:dissociated responsiveness to growth factors nd distinct requirements for a first activation signal
Karray S, Merle-Beral H, Vazquez A, Gerard JP, Galanaud P
Blood, 70, 1105-1110 (1987)

27 Synergistic effect of recombinant IL2 and Interferon on the proliferation of human monoclonal lymphocytes
Karray S, Vazquez A, Merle-Beral H, Olive F, Debré P , Galanaud P
J Immunol 11,3824-3828 ( 1987 )

26 New trends in CLL treatment
Travade P, Chastang C, Dighiero G, Binet JL
Blood

25 Does the CLL B lymphocyte correspond to expansion of an immature B clone or to expansion of a distinct subpopulation of B cells?
Dighiero G, Binet JL
Blood Cells. 12(2):385-97 (1987)

24 Severe infections associated with chronic lymphoid leukemia. 159 infectious episodes in 60 patients
Travade P, Dusart JD, Cavaroc M, Beytout J, Rey M
Presse Med. Oct 11;15(34):1715-8. French (1986)

23 Patient accrual and interim statistical analysis in long-term randomized clinical trials: the French chronic lymphocytic leukemia CLL 80 protocol as a case study
Chastang C, Travade P, Benichou J, Dighiero G, Binet JL
Stat Med. Sep-Oct;5(5):465-73 (1986)

22 Biological aspects of chronic lymphoid leukaemia
Binet JL, Travade P, Chastang C, Dighiero G, Merle-Beral H, Raphael M
C R Seances Soc Biol Fil. 180(5):503-11 (1986)

21 Chronic lymphocytic leukemia, erythroblastopenia, thymolipoma
Lebrun E, Ajchenbaum F, Troussard X, Galateau F, Leporrier M, Lacombe C, et al
Nouv Rev Fr Hematol. 27(1):29-37 (1985)

20 Critical discussion of the assessment of a three-stage prognostic classification for chronic lymphocytic leukaemia
Chastang C, Travade P, and Auquier A
Statistics in Medicine. vol. 4, 287-293 (1985)

19 Complement alternative pathway activation by chronic lymphocytic leukemia cells: its role in their hepatosplenic localization
Praz F, Karsenty G, Binet JL, Lesavre
Blood. Feb;63(2):463-7 (1984)

18 Review, by a group of pathologists, of bone marrow biopsies in chronic lymphocytic leukemia. Apropos of 109 cases with a statistical analysis and anatomo-clinical correlation]
Raphael M, Ployart F, Diebold J, Sultan C, Chomette G, Brousse N, et al
Ann Pathol. 3(2):119-26 (1983)

17 Differentiation ability of the CLL lymphocyte: an immature lymphocyte or an abnormal leukemic cell ?
Dighiero G, Bodega E, Binet JL
Blood Cells. 7(2):331-9 (1981)

16 A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
Binet JL, Auquier A, Dighiero G, Chastang C, Piguet H, Goasguen J, et al
Cancer. Jul 1;48(1):198-206 (1981)

15 New data on the prognosis of chronic lymphoid leukemia
Binet JL.
anatomo-clinical classification Acquis Med Recent. 198:191-200 (1981)

14 A new prognostic classification of chronic lymphocytic leukaemia derived from a multivariate survival analysis
Binet JL, Auquier A, Dighiero G, Chastang C, Piguet H, Goasguen J, Vaugier G, Potron G, Colona P, Oberling F, Thomas M, Tchernia G, Jacquillat C, Boivin P, Lesty C, Duault MT, Monconduit M,  Belabbes S, and Gremy G
Reprinted from Cancer. vol. 48, n°1, July 1 (1981)

13 Differentiation ability of the CLL lymphocyte : an immature lymphocyte or an abnormal leukemic cell ?
Dighiéro G, Bodega E, and Binet JL
Blood Cells. 7, 331-339 (1981)

12 Prognostic value of the study of lymphocytic volumes in chronic lymphocytic leukemia (author's transl)
Dighiero G, Lesty C, Couty MC, Binet JL
Nouv Rev Fr Hematol. 22(4):383-90 (1980)

11 Two new applications of the immunoperoxidase method: cell-by-cell quantitation of surface immunoglobulins and automated recognition of B-lymphocytes
Dighiero G, Bodega E, Mayzner R, Binet JL
Blood Cells. 6(3):371-9 (1980)

10 Individual cell-by-cell quantitation of lymphocyte surface membrane Ig in normal and CLL lymphocyte and during ontogeny of mouse B lymphocytes by immunoperoxidase assay
Dighiero G, Bodega E, Mayzner R, Binet JL
Blood. Jan 55(1):93-100 (1980)

9 Valeur pronostique de l’étude des volumes lymphocytaires dans la leucémie lymphoïde chronique
Dighiero G, Lesty C, Couty MC, et Binet JL
Nouv. Rev. Fr. Hématol. 22, 383-390 (1980)

8 Lymphocyte membrane markers in chronic lymphoid leukemia
Dighiero G
Nouv Rev Fr Hematol. Suppl:VII-IX (1979)

7 Contribution of automation in the classification of chronic lymphocytic leukemia
Binet JL, Dighiero G, Vaugier G , Charron D, Leporrier M, Debré P Merle-Beral H, Raphael M, D’Athis P
Excerpta Medica , 415, 679-82( 1978 )

6 Variations in lymphocyte counts four hours after administration of hydrocortisone in patients with chronic lymphocytic leukaemia
Dighiero G, Vaugier G, Charron D, d'Athis P, Binet JL
Blood. May 49(5):719-28 (1977)

5 The quantification of surface immunoglobulins in lymphoproliferative syndromes
Dighiero G, Follezou JY, Roisin JP, Charron D, Bouvet E, Ternyck T, et al
Nouv Rev Fr Hematol Blood Cells. 18(1):180-1 (1977)

4 Surface immunoglobulins in lymphocytic leukemias
Dighiero G, Follezou JY, Binet JL
Blood. Jul 50(1):179 (1977)

3 Bone-marrow patterns and clinical staging in chronic lymphocyte leukaemia
Charron D, Dighiero G, Raphael M, Binet JL
Lancet. Oct 15, 2(8042):819 (1977)

2 A clinical staging system for chronic lymphocytic leukemia: prognostic significance.
Binet JL, Leporier M, Dighiero G, Charron D, D'Athis P, Vaugier G, et al
Cancer. 40(2), 855-64 (1977)

1 Surveillance of chronic lymphocytic leukemia
Binet JL, Dighiero G, Leporrier M. Follezou JY, Charron D and Debré P
Blood Cells. 3, 651-653 (1977)


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